About
The Papenfuss Lab is a computational biology and bioinformatics research laboratory in the Bioinformatics Division at the Walter and Eliza Hall Institute of Medical Research.
We develop and apply new bioinformatics methods to drive discoveries in cancer and translate these into improved outcome for patients.
Our approach is to use mathematics, statistics and computing to make sense of omics data, especially related to cancer evolution spanning initiation, progression and outcome.
We develop new bioinformatics methods to improve the analysis of cancer multiomics data, including genomic sequencing, transcriptomics, and other omics, spanning bulk, single cell and spatial resolutions. We have a strong track record in developing methods for analysing genome sequencing data, especially for chromosomal rearrangements, and our methods are in use by world-leading sequencing laboratories. A major focus of our research is now the development of new computational and machine learning tools to analyse large, complex multiomics datasets.
Our computational biology research focuses on prostate cancer, melanoma and rare cancers.